ShiQi Yang is the first staff join us via the changping lab. Warmly welcome!
Welcome XianYi Lian to join the Gao lab. Congratulation her on winning the Peking University Boya Postdoctoral Fellowship!
Approximately 97% of the human genome is noncoding. While more than 90% of disease- and trait-associated variants are noncoding variants, their biological functions and mechanisms remain largely elusive. Recently, Gao Lab from Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Center for Bioinformatics (CBI), and State Key Laboratory of Protein Read more about REVA: Systematical curation and evalutation for human expression-modulating variants[…]
Well done, Dr. Shi! Wish you more success and prosperity in days to come!
On July 6th, 2021, Gao Lab from Biomedical Pioneering Innovation Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG) published a research article named “Identifying complex motifs in massive omics data with a variable-convolutional layer in deep neural network” on Briefings in Bioinformatics, proposing a novel convolutional layer for deep neural networks. Deep Read more about A novel convolutional layer with adaptive kernels for effective mining complex patterns in omics data.[…]
The Cell BLAST study (Searching large-scale scRNA-seq databases via unbiased cell embedding with Cell BLAST) was recently awarded by Genomics, Proteomics and Bioinformatics (GPB) as China’s top ten bioinformatics advances of 2020. As a powerful tool for studying cellular heterogeneity, single-cell transcriptomic sequencing has seen rapid development in recent years, with large amounts of data Read more about Cell BLAST for China’s top ten bioinformatics advances of 2020[…]
Well done, Dr. Ke! From a seed to a sapling, and a tree in one day! Wish you more success and prosperity in days to come!
Well done, Dr. Tian! Stick to your way, step by step and you will arrive your destination finally. Wish you more success and prosperity in days to come!
scRNA-seq has seen rapid development over the recent years, providing powerful technological support for studying important biological problems including cellular functions and gene regulatory networks. In a typical scRNA-seq study, cell annotation regarding cell types and cell differentiation progress is usually the first step. However, the standard annotation process is rather tedious, and cannot guarantee Read more about Searching large-scale scRNA-seq databases via unbiased cell embedding with Cell BLAST[…]
Long noncoding RNAs (lncRNAs) have been demonstrated to play many important regulatory roles via various mechanisms (1), and many characteristics have been used to infer their functions. For example, analyzing the natural selection pressures on lncRNAs can reveal whether they are functional (2), and their subcellular localization indicates where they perform functions (3). Functional enrichment Read more about AnnoLnc2: the one-stop portal to systematically annotate novel lncRNAs for human and mouse[…]